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. 2016 Feb 1;6:20092. doi: 10.1038/srep20092

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Forest plots illustrate effect size and 95% confidence intervals (CIs) observed in each contributing study for chromosome 15 (A) and chromosome 4 (B) SNPs with smallest p-values (“top” SNPs). Regional plots show SNPs plotted by their positions on chromosomes against –log₁₀ p-value for their association with cotinine level in genome-wide meta-analysis. The top SNP in each region is highlighted in purple. The SNPs surrounding each top SNP are colour coded to reflect their LD with this variant (see legend). Estimated recombination rates are plotted in pale blue to reflect local LD structure on secondary y-axis. Genome build = hg19; LD population = 1000 Genomes March 2012 release (EUR). Regional plots generated using Locus Zoom.