Tab. II.
Characteristics according to stable vs. unstable anticoagulation. The results are presented as %, mean value ± SD, and median with interquartile range (IQR)
| Total (n = 149) | Stable anticoagulation (TTR ≥ 80%), n = 75 | Unstable anticoagulation (TTR < 80%), n = 74 | p |
|---|---|---|---|
| Age (years) | 67.6 ± 12.3 | 67.9 ± 13.0 | NS |
| BMI (kg/m2) | 27.5 ± 3.99 | 29.8 ± 5.32 | 0.006 |
| CHA2DS2-VASc score | 3.1 ± 1.6 | 3.6 ± 1.6 | 0.089 |
| HAS-BLED | 1.0 ± 0.84 | 1.2 ± 0.7 | 0.078 |
| Ejection fraction (%) | 51.6 ± 12.0 | 51.2 ± 13.8 | NS |
| Dose of warfarin daily (mg) | 4.7 ± 1.26 | 4.6 ± 1.76 | NS |
| Dose of warfarin weekly (mg) | 32.6 ± 9.01 | 31.9 ± 12.3 | NS |
| Laboratory results | |||
| Haemoglobin (g/dl)* | 13.9 (12.8-15.2) | 14 (12.8-14.8) | NS |
| Platelets (103/µl) | 215.7 ± 92.9 | 212.8 ± 67.5 | NS |
| Sodium (mmol/l) | 138 ± 2.35 | 136 ± 16.3 | NS |
| Potassium (mmol/l) | 4.31 ± 0.55 | 4.23 ± 0.48 | NS |
| Urea (mg/dl)* | 6.55 (4.8-7.9) | 6.63 ± 2.83 | NS |
| GFR (ml/min/1.72 m2) | 87.9 ± 34.1 | 87.7 ± 34.6 | NS |
| Glucose (mmol/l) | 5.9 ± 1.29 | 5.8 ± 1.26 | NS |
| TCh (mmol/l)* | 4.65 (3.75-5.25) | 4.5 ± 1.18 | NS |
| LDL (mmol/l) | 2.6 ± 1.14 | 2.4 ± 0.99 | NS |
| HDL (mmol/l)* | 1.31 (1.07-1.48) | 1.4 ± 0.71 | NS |
| TG (mmol/l) | 1.3 ± 0.57 | 1.4 ± 0.6 | NS |
| ALT (IU/l) | 29.2 ± 17.4 | 26.4 ± 13.7 | NS |
| AST (IU/l) | 27.8 ± 12.7 | 25.5 ± 9.1 | NS |
| hsCRP (mg/dl) | 4.0 ± 5.9 | 5.7 ± 6.1 | 0.081 |
| Fibrinogen (g/l) | 3.8 ± 1.5 | 4.12 ± 1.6 | NS |
| D-dimers (µg/ml) | 1.02 ± 1.4 | 1.01 ± 1.4 | NS |
| Clinical data (%) | |||
| Arterial hypertension | 69 | 86 | 0.01 |
| Previous stroke | 12 | 13 | NS |
| Coronary artery disease | 53 | 50 | NS |
| Heart failure | 12 | 8 | NS |
| Diabetes | 24 | 32 | NS |
| Dyslipidaemia | 68 | 75 | NS |
| Bleedings | 6.7 | 16.2 | 0.06 |
| Interruption of anticoagulant therapy (%) | 6.6 | 6.8 | NS |
| Medications (%) | |||
| Aspirin | 36 | 39 | NS |
| Clopidogrel | 24 | 16 | NS |
| Amiodarone | 9.3 | 18.9 | 0.09 |
| Antibiotics | 5.3 | 5.4 | NS |
BMI – body mass index, GFR – glomerular filtration rate, TCh – total cholesterol, LDL – low density lipoproteins, HDL – high density lipoproteins, TG – triglycerides, ALT – alanine aminotransferase, AST – aspartate aminotransferase, hsCRP – high sensitivity C-reactive protein, CAD – coronary artery disease, SD – standard deviation, IQR – interquartile range.
*
non-normal data