Table 2. Polymorphisms of NOD1//rs2075818 and CIITA//rs12932187 in Behcet’s Disease.
| SNPs | Stage | Genotype | Cases, No. |
Controls, No. |
P Value | Pc Value | OR (95% CI) | ||
|---|---|---|---|---|---|---|---|---|---|
| Allele | (Frequency) | (Frequency) | |||||||
| rs12932187 (CIITA) | Firsta | CC | 113 | (0.298) | 233 | (0.405) | 8.212E-04 | 4.927 E-02 | 0.625 (0.474 to 0.824) |
| CG | 204 | (0.538) | 280 | (0.486) | 0.115 | NS | 1.232 (0.950 to 1.598) | ||
| GG | 62 | (0.164) | 63 | (0.109) | 0.015 | NS | 1.593 (1.093 to 2.323) | ||
| C | 430 | (0.567) | 746 | (0.648) | 4.169E-04 | 1.668E-02 | 0.713 (0.591 to 0.861) | ||
| G | 328 | (0.433) | 406 | (0.352) | 4.169E-04 | 1.668E-02 | 1.402 (1.162 to 1.691) | ||
| Replicationb | CC | 170 | (0.304) | 359 | (0.416) | 1.878E-05 | 1.120E-02 | 0.612 (0.489 to 0.767) | |
| CG | 298 | (0.533) | 408 | (0.473) | 0.028 | NS | 1.270 (1.026 to 1.573) | ||
| GG | 91 | (0.163) | 95 | (0.110) | 0.004 | NS | 1.570 (1.152 to 2.140) | ||
| C | 638 | (0.571) | 1126 | (0.653) | 9.586E-06 | 3.835E-04 | 0.706 (0.605 to 0.824) | ||
| G | 480 | (0.429) | 598 | (0.347) | 9.586E-06 | 3.835E-04 | 1.417 (1.214 to 1.653) | ||
| Combinedc | CC | 283 | (0.302) | 592 | (0412) | 5.552E-08 | 3.331E-06 | 0.617 (0.519 to 0.735) | |
| CG | 502 | (0.535) | 688 | (0.478) | 0.007 | NS | 1.255 (1.064 to 1.480) | ||
| GG | 153 | (0.163) | 158 | (0.110) | 1.693E-04 | 1.016E-05 | 1.579 (1.243 to 2.006) | ||
| C | 1068 | (0.569) | 1872 | (0.651) | 1.501E-08 | 6.004E-07 | 0.709 (0.629 to 0.799) | ||
| G | 808 | (0.431) | 1004 | (0.349) | 1.501E-08 | 6.004E-07 | 1.411 (1.252 to 1.589) | ||
| rs2075818 (NOD1) | First | CC | 235 | (0.618) | 299 | (0.525) | 0.004 | NS | 1.469 (1.128 to 1.913) |
| CG | 130 | (0.342) | 217 | (0.381) | 0.226 | NS | 0.846 (0.645 to 1.109) | ||
| GG | 15 | (0.040) | 54 | (0.094) | 0.001 | NS | 0.393 (0.218 to 0.707) | ||
| C | 600 | (0.789) | 825 | (0.724) | 1.173E-03 | 4.694E-02 | 1.432 (1.152 to 1.780) | ||
| G | 160 | (0.211) | 315 | (0.276) | 1.173E-03 | 4.694E-02 | 0.698 (0.562 to 0.868) | ||
| Replicationb | CC | 328 | (0.588) | 431 | (0.502) | 0.002 | NS | 1.416 (1.142 to 1.756) | |
| CG | 193 | (0.346) | 341 | (0.397) | 0.052 | NS | 0.803 (0.644 to 1.002) | ||
| GG | 37 | (0.066) | 87 | (0.101) | 0.023 | NS | 0.630 (0.422 to 0.940) | ||
| C | 849 | (0.761) | 1203 | (0.700) | 4.29E-04 | 1.715E-02 | 1.361 (1.146 to 1.617) | ||
| G | 267 | (0.239) | 515 | (0.300) | 4.29E-04 | 1.715E-02 | 0.735 (0.619 to 0.872) | ||
| Combinedc | CC | 563 | (0.601) | 730 | (0.511) | 1.941E-05 | 1.164E-03 | 1.438 (1.217 to 1.699) | |
| CG | 323 | (0.344) | 558 | (0.390) | 0.023 | NS | 0.820 (0.691 to 0.973) | ||
| GG | 52 | (0.055) | 141 | (0.099) | 1.703E-04 | 1.022E-02 | 0.536 (0.386 to 0.745) | ||
| C | 1449 | (0.772) | 2028 | (0.710) | 1.703E-06 | 6.811E-05 | 1.389 (1.214 to 1.589) | ||
| G | 427 | (0.228) | 830 | (0.290) | 1.703E-06 | 6.811E-05 | 0.720 (0.629 to 0.824) | ||
NS = no significant difference; OR = odds ratio; Pc = P value with Bonferroni correction.
SNP = single nucleotide polymorphism.
aFirst stage (stage 1), case-to-control ratio: 380:576; bReplication stage (stage 2), case-to-control ratio: 559:862; cCombined stage(a+b), case-to-control ratio: 939:1438.