Table 1.
Exonal mutations in all of 12 exons of TP53 gene in the different grades of TCC
| Grade I of TCC (18 patients, 30%, normal patients: 5) | ||||||||||||
| Mutations/exons | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 |
| Deletion | 4 Ps | – | – | – | 1 P | – | – | – | – | – | 2 Ps | 2 Ps |
| Duplication | 1 P | – | – | – | – | 2 Ps | – | 3 Ps | – | – | – | – |
| Grade II of TCC (22 patients, 37%, normal patients: 9) | ||||||||||||
| Deletion | 4 Ps | – | – | 2 Ps | 1 P | – | – | – | 2 Ps | – | 1 P | 3 Ps |
| Duplication | 2 Ps | – | 1 P | – | – | 4 Ps | – | 1 P | 2 Ps | – | – | – |
| Grade III of TCC (13 patients, 22%, normal patients: 7) | ||||||||||||
| Deletion | 1 P | 1 P | – | 1 P | 1 P | – | – | – | 1 P | – | – | – |
| Duplication | 1 P | – | – | – | – | 1 P | 2 Ps | – | – | – | – | – |
| Grade IV of TCC (seven patients, 11%, normal patients: 3) | ||||||||||||
| Deletion | 2 Ps | – | 1 P | – | – | – | – | – | – | – | 1 P | – |
| Duplication | – | – | – | – | – | – | 1 P | 2 Ps | 1 P | – | – | – |
| Total deletion | 11 | 1 | 1 | 3 | 3 | – | – | – | 3 | – | 4 | 5 |
| Total duplication | 4 | – | 1 | – | – | 7 | 3 | 6 | 3 | – | – | – |
Some of patients had both deletion and duplication or had more than one mutation. TCC, transitional cell carcinoma; P, patient.