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. 2015 Dec 29;5(2):337–351. doi: 10.1002/cam4.579

Figure 2.

Figure 2

Schematic map of ETV6 wild‐type, RUNX1 wild‐type, and 4 ETV6‐RUNX1 translocation models at the genomic level. Breakpoints are located between exon 5 and exon 6 of ETV6 and exon 1 and exon 2 of RUNX1. Pink and blue arrows show the directions of chromosomes. (A) Intron 5 of ETV6 (including exons 1–5) directly fuses with intron 1 of RUNX1 (exon 1), forward chr12 chain fuses with forward chr21 chain. (B) Intron 1 of RUNX1 (including exons 2–8) directly fuses with intron 5 of ETV6 (including exons 6–8), reverse chr12 chain fuses with reverse chr21 chain. (C) Intron 5 of ETV6 (including exons 1–5) fuses with intron 1 of RUNX1 (including exons 2–8), which has flipped horizontally and vertically, forward chr12 chain fuses with reverse chr21 chain. (D) Intron 1 of RUNX1 (exon 1) flips horizontally and vertically and fuses with intron 5 of ETV6 (including exons 6–8), reverse chr12 chain fuses with forward chr21 chain.