Figure 5. Specific inhibition of the Kv channel family in the ophthalmic artery of wild type mice indicated an active participation of this channel subtype in mediating the agonist-evoked vasodilatory mechanisms.
(A) Blocking with MgTXalmost abolished dilatory responses of the arteries. (B)The inhibition of Kv1.1, Kv1.2 and Kv1.6 channels with α-DTX demonstrated a significantabolishment of vasodilation. Values are expressed as mean ± s.e.m [n = 5–6 per group; ***P < 0.001, L-NAME and Indomethacin vs L-NAME and Indomethacin and blocker(s)]. Absence of error bar indicates that the SEM was less than the size of the symbol.