Table 1. Chemical shift changes of representative amide nitrogen, methyl protons, and methyl carbons for the oxygen binding to L99A.

nucleus	Δδ_max/ppma	Std. Error
K85 N	0.8	0.12
Y88 N	5.3	0.7
D89 N	0.5	0.10
A99 N	2.1	0.2
I100 N	0.6	0.10
L118 N	0.8	0.12
I78 Hδ1	0.39	0.06
I78 Hγ2	0.32	0.06
M102 Hε	0.61	0.08
I78 Cδ1	2.3	0.2
I78 Cγ2	2.7	0.3
M102 Cε	3.9	0.4

^aΔδ are obtained by a global fitting for changes in chemical shifts using eq. 1.