Table 1. Participant characteristics.
Statistics shown are of the form mean (SD) unless otherwise specified.
| A+N+ (n = 45) |
A+N− (n = 17) |
A−N+ (n = 22) |
A−N− (n = 12) |
|
|---|---|---|---|---|
| Male, no. (%) | 29 (64%) | 11 (65%) | 18 (82%) | 10 (83%) |
| Age, yrs | 81 (5) | 79 (5) | 82 (5) | 79 (5) |
| Education, yrs | 14 (3) | 14 (4) | 15 (4) | 12 (3) |
| APOE e4 carrier, no. (%) | 23 (51%)a | 10 (59%) c | 2 (9%) | 0 |
| PIB SUVR | 2.11 (0.48)a | 1.95 (0.33)c | 1.31 (0.03) | 1.34 (0.06) |
| FDG SUVR in AD signature meta-ROI | 1.25 (0.14)b | 1.44 (0.10) | 1.27 (0.15)d | 1.44 (0.10) |
| Adjusted Hippocampal Volume | −2.81 (0.82)b | −1.75 (0.55) | −2.52 (0.67)d | −1.81 (0.47) |
| Total Intracranial volume (L) | 1.5 (0.1) | 1.5 (0.1) | 1.6 (0.2) | 1.5 (0.1) |
| Mini-Mental state exam | 25 (2.7) | 26 (2.0) | 26 (2.3) | 27 (1.3) |
| Annual change in MMSE† | −1.1 (0.20)i | −0.2 (0.32) | 0.2 (0.31) | −0.1 (0.39) |
| Global z-scores* | −0.74 (0.84)e | −0.29 (0.42) | −0.44 (0.91) | −0.44 (1.18) |
| Memory z-scores* | −1.23 (0.84)f | −0.74 (0.65) | −0.63 (0.93) | −0.68 (1.15) |
| Attention z-scores* | −0.23 (1.17) | 0.20 (0.92) | −0.46 (1.27) | −0.23 (1.10) |
| Language z-scores* | −0.75 (1.17)g | −0.16 (0.91) | −0.36 (0.69) | −0.27 (1.08) |
| Visual spatial z-scores* | −0.13 (1.00) | 0.05 (0.81) | 0.25 (1.25) | −0.34 (1.37) |
| Amnestic MCI, no. (%) | 41 (91%) | 16 (94%) | 19 (86%) | 9 (75%) |
| Mean number of Visits with imaging | 2 (0.7) | 2 (0.5)h | 2 (0.4) | 2 (0.3) |
| Those with 2 imaging visits | 33 (73%) | 10 (59%) | 17 (77%) | 11 (92%) |
| Those with ≥ 3 imaging visits | 12 (27%) | 7 (41%) | 5 (23%) | 1 (8%) |
| Range | 2 to 6 | 2 to 3 | 2 to 3 | 2 to 3 |
| Time in study, yrs | 2.1 (1.10) | 2.2 (0.99) | 1.9 (1.00) | 2.1 (1.03) |
| Range, yrs | 1 to 5 | 1 to 4 | 1 to 4 | 1 to 4 |
FDG = 18fluorodeoxyglucose positron emission tomography; PiB = Pittsburgh compound B positron emission tomography; SUVR = standardized uptake value ratio
z-scores derived from entire sample of 70+ year olds who were cognitively normal or who were diagnosed with MCI in the MCSA14
Estimates of mean change (standard error) in MMSE are from a linear mixed effects model. The mean change is estimated for an 80-year old participant. One participant was missing follow-up MMSE data and was not included in the model.
A+N+ differs from A−N+ and A−N−, p ≤ 0.001
A+N+ differs from A+N− and A−N−, p ≤ 0.001
A+N− differs from A−N+ and A−N−, p ≤ 0.001
A−N+ differs from A+N− and A−N−, p ≤ 0.001
A+N+ differs from A+N−, p=0.01
A+N+ differs from A+N− and A−N+, both p=0.02
A+N+ differs from A+N−, p=0.049
A+N− differs from A−N−, p=0.04
A+N+ differs from A+N−, A−N+, A−N−, p < 0.026
p-values are for descriptive purposes; none are corrected for multiple testing