Body weight changes. Body weight changes in nonalcoholic steatohepatitis (NASH) (solid red line, n = 8, male) and normal (dashed blue line, n = 8, male) rats from 8 to 12 weeks of age. Each point was expressed as mean ± SD, and statistical significance is shown by asterisks (p < 0.01). NASH rats were injected with 200 mg/kg streptozotocin 2 days after birth and fed a high-fat diet as described in the text.