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. 2016 Jan 21;7:10388. doi: 10.1038/ncomms10388

Figure 3. 5-HT-SER-7 signalling activates axon regeneration via GPA-12 and RHGF-1.

Figure 3

(a,d) Percentages of axons that initiated regeneration 24 h after laser surgery. Error bars indicate 95% CI. ***P<0.001; **P<0.01; *P<0.05; NS, not significant (Fisher's exact test, two-tailed, n≥50). (b) SER-7 signalling pathway. SER-7 activates the GPA-12-RHGF-1-RHO-1 pathway. Activation of RHO-1 inhibits DGK-1, leading to a stabilization of DAG levels. (c) Structure of RHGF-1. Schematic diagrams of RHGF-1 and its human counterpart are shown. Domains are shown as follows: a PDZ domain, a regulator of G protein signalling domain (RGS), a Dbl homology domain (DH) and a Pleckstrin homology domain (PH). The bold lines underneath indicate the extent of the deleted regions in the rhgf-1(ok880) and rhgf-1(gk217) mutants.