Table 1.
Binding specificities of representative PH domains.
| Group 1 | Group 2 | Group 3 | Group 4 | |
|---|---|---|---|---|
| PI(3,4,5)P3/Ins(1,3,4,5)P4 | +a | + | + | − |
| PI(4,5)P2/Ins(1,4,5)P3 | − | + | − | − |
| PI(3,4)P2/Ins(1,3,4)P3 | − | − | + | − |
| PH domain | Btk, Grp1, Gap1m
Gap1IP4BP, Vav, cytohesin-1, Sos, ARNO, TIAM1-N |
PLCδ1, βArk, β-spectrin, DAGKδ, RasGAp, OSBP, IRS-1, Plec-N | Dapp1, Akt, PDK1 | Dynamin, TIAM1-C |
a+, − represent specific binding or nonspecific binding. Gap1IP4BP represents one of the members of Ras GTPase-activating proteins and Gap1m represents the mammalian counterpart of the Drosophila Gap1 gene.