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Effects of 0.5% bupivacaine on chronic arthritic pain induced by MIA. (a) Weight load and (b) mechanical allodynia were evaluated before and 30, 60, 90, 120, and 180 min after 0.5% bupivacaine or saline injection into the OA knee joint. Groups marked with asterisks (0.5% bupivacaine 20 μL) or number signs (0.5% bupivacaine 10 μL) indicate a statistically significantly difference from the saline group (∗ p < 0.05, # p < 0.05).
