Table 3.
D with E2 ± T add-back had little safety impact on cognition or laboratory parameters and did not cause endometrial hyperplasia. Values are means (SEM) or percentages; ∗ indicates a statistically significant difference relative to baseline values, p ≤ 0.05.
| Baseline N = 20 |
3 months N = 20 |
6 months N = 20 |
|
|---|---|---|---|
| MOQ total | — | — | — |
| Concentration | 7.6 (0.6) | 6.4 (0.6) | 6.2 (0.6)∗ |
| Nonverbal | 8.1 (0.3) | 7.8 (0.4) | 7.5 (0.4) |
| Prospective | 7.8 (0.4) | 7.5 (0.5) | 7.2 (0.5) |
| Real world | 8.1 (0.4) | 8.1 (0.5) | 7.3 (0.5) |
| Superlative | 3.2 (0.4) | 3.3 (0.4) | 2.8 (0.5) |
| Verbal | 7.3 (1.4) | 7.0 (0.5) | 6.5 (0.5) |
| Serum lipids | — | — | — |
| Cholesterol | 204.3 (9.4) | — | 202.2 (10.0) |
| HDL | 65.2 (2.4) | — | 63.6 (3.5) |
| LDL | 121.1 (9.5) | — | 115.2 (9.7) |
| VLDL | 18.1 (1.8) | — | 23.4 (2.9)∗ |
| Triglycerides | 90.5 (9.2) | — | 117.1 (14.6)∗ |
|
| |||
| Baseline N = 20 |
6 months N = 20 |
||
|
| |||
| Complete blood count | — | — | — |
| White blood cells | 6.1 (0.4) | — | 5.9 (0.4) |
| Hemoglobin | 12.8 (0.2) | — | 13.0 (0.2) |
| Platelets (000) | 304 (16.3) | — | 275 (16.3)∗ |
|
| |||
| Baseline N = 17 |
6 months N = 16 |
||
|
| |||
| Endometrial biopsy | — | — | — |
| Proliferative | 100% | — | 100% |
| Hyperplasia | 0% | — | 0% |
| Atrophic | 0% | — | 0% |