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Plasma concentrations of proteinergic RAGE ligands after trauma. HMGB1 (a), S100A8 (b), and S100A12 (c) levels at admission (n = 16/10/10 for trauma/surgical/healthy) and 2 d (n = 16), 4 d (n = 15), 6 d (n = 11), and 8 d after trauma (n = 11). ∗ P < 0.05, ∗∗ P < 0.01, and ∗∗∗ P < 0.001 compared to trauma at admission (Mann-Whitney U).
