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. 2015 Nov 30;4(12):1744–1752. doi: 10.1242/bio.013078

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© 2015. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — Electrophysiological properties of PKD-iPSCs derived neurons. (A) Cells were held at −70 mV, and inward sodium currents were elicited by voltage steps from −70 to +30 mV in 10 mV increments for CON (red) and PKD (blue) iPS derived neurons. (B) Current injection-induced action potential of both CON- and PKD-iPSC-induced neurons. (C) Representative traces show systematic increase in I_A generated by the hyperpolarizing prepulses. (D) Both CON- and PKD-iPSC-induced neurons could generate sodium current using the same pulse protocol as in A. (E) Statistical analysis of C. The I_A currents showed no differences between CON- and PKD-iPSC-induced neurons when normalized to the peak current. To test whether different path voltage will influence the I_A current between the two groups two-way ANOVA was used for the data analysis. (F) Statistical analysis of D. No significant difference was detected of the fast activated and deactivated sodium currents between the CON- and PKD-iPSC-induced neurons. Two-way ANOVA was used for the data analysis. Error bars represent s.e.m.