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. 2016 Jan 20;7:10416. doi: 10.1038/ncomms10416

Figure 2. Early visual experience causes precocious closure of the ACx CPs of sensitivity to hearing loss.

Figure 2

(a) Diagram shows the experimental design for data presented in b–i. Eyes were opened prematurely at P14 and ears were plugged on P15 or P16. Some animals receiving earplugs on P16 were dark reared from P14 to P17. Sample size; IPSCs: Control, n=40; P15, n=12; P16, n=14; P16 Dark rear, n=21; Intrinsic: Control, n=57; P16, n=26; P16 Dark rear, n=16. (b–d) Bar plots show that after early eyelid opening, sIPSC amplitude and frequency were diminished and decay time constant was slower when earplugs were inserted on P15, but not P16. Early CP closure was prevented by dark rearing. (e,f) Bar plots show that after early eyelid opening meIPSC amplitude was diminished and PPRs were depressed when ears were plugged at P15, but not P16. Dark rearing prevented early closure of the CP. (g–i) Bar plots show that after early eyelid opening the ΔmV did not decrease, depolarizing sag was not reduced and there was not a decrease in firing rate when ears were plugged on P16. Dark rearing prevented early closure of the CP. Experiments were not replicated. Tukey's (honestly significant different) test, *P<0.05, **P<0.01, ***P<0.001. Error bars are s.e.m.