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. 2016 Jan 20;7:10416. doi: 10.1038/ncomms10416

Figure 5. Very early eyelid opening at P11 coupled with transient hearing loss from P11 to P13 led to persistent inhibitory deficits in adults.

Figure 5

(a) Diagram shows the experimental design for data presented in b–d. One group of animals received transient hearing loss from P11 to P13 and then experienced normal hearing and vision (eyes open P18) until the day of recording (P86–P92). Another group of animals experienced transient hearing loss from P11 to P13 but also had their eyes opened on P11. Animals then experienced normal hearing and vision until the day of recording (P86–P92). Sample size; IPSCs: Control, n=21; earplug P11 to 13, n=15; Early earplug P11 to 13, n=14. (b–d) Bar plots show complete recovery of sIPSC amplitude, frequency and decay constant in adults when earplugs were removed at P13 and eyes opened normally at P18. In contrast, sIPSC amplitude and frequency were diminished and decay time constants were slower in adults when eyes were opened very early, indicating very premature closure of the CP. Experiments were not replicated. Tukey's (honestly significant different) test, *P<0.05, **P<0.01, ***P<0.001. Error bars are s.e.m.