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. 2016 Feb 1;7:20. doi: 10.1186/s13287-016-0280-9

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© Tao et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Transgene expression in chondrogenically-induced hMSCs upon administration of rAAV vectors. hMSC aggregates were transduced with the various vectors or vector combinations as described in Fig. 1 and in Methods. Samples were histologically processed after 21 days to detect the expression of TGF-β and SOX9 by immunohistochemistry (magnification × 4; all representative data) a and to monitor the production of TGF-β by ELISA b as described in Methods. **Statistically significant compared with group 1 (rAAV-lacZ) (**P ≤0.010). TGF-β transforming growth factor beta