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. 2016 Feb 1;7:20. doi: 10.1186/s13287-016-0280-9

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© Tao et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Metabolic and differentiation activities in chondrogenically-induced hMSCs upon administration of rAAV vectors. hMSC aggregates were transduced with the various vectors or vector combinations as described in Fig. 1 and in Methods. Samples were histologically and histomorphometrically processed after 21 days to evaluate cellularity (H & E staining; magnification × 20) a, b and the deposition of matrix proteoglycans (toluidine blue staining; magnification × 4) a, c and type II collagen (magnification × 4) a, d as described in Methods (all representative data). *,**Statistically significant compared with group 1 (rAAV-lacZ) (*P ≤0.050; **P ≤0.010). H & E hematoxylin and eosin, TGF-β transforming growth factor beta