Fig. 7.

ILK mediates OPC migration on PDL. a Confocal images of Ilk ^−/− and Ilk ^fl/fl OPCAs migrated on PDL for 4, 10 and 24 h. b As compared to Ilk ^fl/fl OPCs, Ilk ^−/− OPCs were more concentrated in the 10, 20 and 40 μm proximal concentric rings at 4, 10 and 24 h respectively. c No difference in the total number of migrated Ilk ^−/− versus Ilk ^fl/fl OPCs was observed at 10 or 24 h, although significantly fewer Ilk ^−/− OPCs had migrated at the 4 h time point. d There was no difference in the diameters of Ilk ^−/− versus Ilk ^fl/fl OPCAs prior to commencement of the assay for any of the time points assessed. Data represent the mean ± SEM (n = 4). For b, **p < 0.01; ***p < 0.001 (repeated measures two-way ANOVA followed by Bonferroni post-tests). For c and d, **p < 0.01 (Student’s t test). Scale bars, 50 μm