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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Drug Deliv Transl Res. 2016 Feb;6(1):1–16. doi: 10.1007/s13346-015-0269-4

Figure 6. Anti-HIV-1 activity of APV-PEG3.4kDa-Bac7 CPP (APB), APV-PEG3 4kDa-FITC (APF) and free APV.

Figure 6

The anti-HIV-1 activity was determined by the inhibition of syncytium formation in HIV-1 infected MT-2 T-cells and expressed as % of syncytium count of no treatment. Non-linear curve-fitting using the dose-response equation was used to determine the IC50 values. The R2 values of the curve fitting are 0.9672 for APV, 0.9067 for APF and 0.9511 for APB. APF activity (IC50 = 8064 nM) was significantly lower than APV (IC50 = 50.29 nM) (p<0.001). Further conjugation with Bac7 CPP (i.e., the APB NC, IC50 = 78.29 nM) almost completely restored APV activity with no significant difference in IC50 values (p>0.05). Data are reported as mean ± SD of three independent experiments.