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. 2016 Feb 2;11:16. doi: 10.1186/s13014-016-0590-1

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© Aly et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Dose (left column and BED (right column) distribution for a representative case using the sequential boost and the simultaneously integrated boost schemes employing the same prescribed biologically effective dose with α/β = 3 Gy for all OARs and α/β = 10 Gy for target volumes in 28 fractions. Due to the difference in α/β, the maximum BED values occur outside the target volumes (red arrows)