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. 2016 Feb 2;11:16. doi: 10.1186/s13014-016-0590-1

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© Aly et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Cumulative dose (a and b) and BED (c and d) volume histograms of the representative case using sequential boost (solid line) and the corresponding simultaneously integrated boost (dotted line) plans. The BED was calculated using the same prescribed biologically effective dose with α/β = 3 Gy for OARs and α/β = 10 Gy (a and c) and 3 Gy (b and d) for boost and breast target volumes