. 2015 Dec 31;2015:424813. doi: 10.1155/2015/424813

Table 2.

Effect of metformin or sitagliptin on the histopathology in DOX-induced cardiotoxicity in rats.

Parameter	Control	Metformin	Sitagliptin	DOX	Metformin/DOX	Sitagliptin/DOX
Myocardial degeneration	0 ± 0	0 ± 0	0 ± 0	2.00 ± 0.27^a	0.25 ± 0.04^b	0.50 ± 0.03^b
Interstitial inflammation	0 ± 0	0 ± 0	0 ± 0	2.75 ± 0.32^a	0.50 ± 0.02^b	1.00 ± 0.07^ab
Interstitial hemorrhage	0 ± 0	0 ± 0	0 ± 0	2.25 ± 0.21^a	0.75 ± 0.03^ab	0.50 ± 0.02^b

Data were expressed as mean ± SEM of six observations.

^aSignificantly different from control group (P < 0.05).

^bSignificantly different from doxorubicin group (P < 0.05).