. 2015 Dec 31;2015:424813. doi: 10.1155/2015/424813

Table 3.

Effect of metformin or sitagliptin on the immunohistochemical enzymatic expression of COX-2, iNOS, and caspase-3 in DOX-induced cardiotoxicity in rats.

Parameter	Control	Metformin	Sitagliptin	DOX	Metformin/DOX	Sitagliptin/DOX
COX-2	1.25 ± 0.42	1.50 ± 0.54	1.25 ± 0.23	3.75 ± 0.43^a	2.00 ± 0.32^ab	2.50 ± 0.58^ab
iNOS	1.75 ± 0.28	1.50 ± 0.28	1.50 ± 0.28	3.50 ± 0.35^a	2.25 ± 0.36^b	2.75 ± 0.24^ab
Caspase-3	1.25 ± 0.35	1.00 ± 0.42	1.25 ± 0.36	3.75 ± 0.52^a	1.75 ± 0.25^b	2.25 ± 0.37^ab

Data were expressed as mean ± SEM of six observations.

^aSignificantly different from control group (P < 0.05).

^bSignificantly different from doxorubicin group (P < 0.05).