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. 2016 Feb 1;16:53. doi: 10.1186/s12879-016-1378-5

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© Anderson et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Histology of core biopsy from supraclavicular lymph node and radiological findings including a diagnostic FDG-positron emission tomography (PET) scan and comparative abdominal computed tomography before and after rituximab monotherapy. a PET scan performed during Admission #5 demonstrates widespread avid lymphadenopathy prior to the diagnosis of multi-centric Castleman’s disease (MCD). Images (b) and (c) show splenomegaly on computed tomography (CT) also during Admission #5. Images (d) and (e) were taken following four doses of rituximab therapy. The spleen has decreased in size from a maximum length of 15.5 cm (superioinferiorly) to 12.9 cm. f Low power showing regressed germinal centre and expanded interfollicular zones (H&E, x 100). g High power of interfollicular zone showing plasma cell proliferation (H&E, x 400). h Immunohistochemical staining for HHV-8 shows nuclear expression in isolated cells in the mantle zone (x 200)