Fig. 7.
RGS10-null Th1 but not Th17 cells adoptively transferred into WT mice conferred attenuated EAE. RGS10-null or WT mice (n = 6) were immunized with MOG35–55/CFA.. Nine days later, splenocytes and lymph node cells were harvested from RGS10-null and WT mice and then differentiated in vitro into Th1 cells or Th17 cells as described in the “Methods” section. Th1 or Th17 cells from RGS10-null or WT mice were injected into 5- to 6-week-old WT naïve recipient mice; mice were followed clinically up to at least day 32. Mean clinical scores (±SEM) of RGS10 WT adoptive transfer recipients of encephalitogenic Th1 (a) or Th17 (b) cells from MOG35–55-immunized WT and RGS10-null donors. *p < 0.05, Mann-Whitney U test