Table 3.
Body weight, relative kidney weight, and renal function in BALB/cOlaHsd mice 4 days after cisplatin administration.
Control | MSCs | ATG | ATG + MSCs | CIS | CIS + MSCs | ATG + CIS | ATG + CIS + MSCs | |
---|---|---|---|---|---|---|---|---|
Body weight (g), day 0 | 27.3 ± 0.6 | 25.6 ± 1.2 | 27.6 ± 2.2 | 27.4 ± 2.7 | 24.9 ± 0.7 | 24.6 ± 0.8 | 26.6 ± 0.4 | 26.9 ± 0.3 |
Body weight change (g) (day 0–day 4) | 0.9 ± 0.4b | 0.2 ± 0.2b | 0.3 ± 0.4b | 0.5 ± 0.4b |
(−) 5.1 ± 0.8a |
(−) 4.8 ± 0.5a |
(−) 4.8 ± 0.4a |
(−) 4.5 ± 0.9a |
Kidney relative weight ×100 | 1.68 ± 0.05ab | 1.69 ± 0.06ab | 1.67 ± 0.05ab | 1.74 ± 0.05ab | 1.71 ± 0.27b | 1.67 ± 0.17ab | 1.79 ± 0.19b | 1.51 ± 0.06a |
BUN (mmol/L) | 8.05 ± 0.77b | 7.43 ± 0.2b | 8.4 ± 0.47b | 6.95 ± 0.37b | 43.87 ± 6.57a | 42.7 ± 4.63a | 40.26 ± 6.84a | 31.34 ± 3.99a |
Creatinine (μmol/L) | 30.5 ± 0.77bc | 18.0 ± 0.2bc | 18.25 ± 0.47bc | 31.5 ± 7.63bc | 83.67 ± 19.43a | 48.0 ± 16.83b | 42.0 ± 3.96bc | 27.5 ± 1.91c |
ANOVA followed by Duncun multicomparison test; results are expressed as mean ± SEM; values with different superscript letters in rows are statistically different (p < 0.05). ATG + CIS + MSCs: cisplatin treated with single injection of MSCs pretreated with ATG, ATG + CIS: cisplatin, pretreated with ATG, ATG + MSCs: treated with single injection of MSCs pretreated with ATG, ATG: treated with ATG, CIS + MSCs: cisplatin treated with single injection of MSCs, CIS: cisplatin treated, and MSCs: treated with single injection of MSCs.