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. 2015 Nov 26;22(1):116–119. doi: 10.1002/chem.201504343

Scheme 1.

Scheme 1

A) Radical cyclization cascade of a dialdehyde in the first enantiospecific synthesis of (+)‐pleuromutilin. B) Industrially‐important pleuromutilin analogues and the traditional method of analogue synthesis. C) This work: CuI and SmII in a short route to re‐engineered pleuromutilin cores.