Table 5.
Odds ratios and 95% confidence intervals obtained with time-oriented risk models of chronic lung disease for three patterns of respiratory disease (Low FiO2, Pulmonary Deterioration [PD], or Early and Persistent Pulmonary Dysfunction [EPPD]) during the first four postnatal weeks.
| 1. Antenatal | Low FiO2 | PD | EPPD |
|---|---|---|---|
| GA 23–24 wks | 3.2 (2.0, 8.8) | 2.5 (1.5, 4.3) | |
| GA 25–26 wks | 1.9 (1.1, 3.1) | ||
| BW Z-score < −1 | 26 (7.0, 95) | 4.4 (2.3, 8.2) | 2.0 (1.1, 3.9) |
| Male | 1.9 (1.2, 3.1) | ||
| Cesarean delivery | 0.5 (0.2, 1.2) | ||
| Indication is PE or FI | 1.9 (0.98, 3.8) | ||
| 2. Early neonatal (week 1) | |||
| SNAP-IITM 30+ | 3.3 (1.02, 11) | 2.0 (1.1, 3.9) | |
| Definite bacteremia | 2.6 (1.01, 6.9) | ||
| Surfactant | 0.2 (0.1, 0.7) | ||
| Mechanical ventilation on day 7 | 1.5 (0.5, 3.9) | 4.2 (2.5, 6.9) | 2.7 (1.5, 4.7) |
| 3. Late neonatal (weeks 2–4) | |||
| Dexamethasone | 3.0 (1.2, 7.2) | ||
| Analgesic | 3.4 (1.2, 9.5) | ||
| PTX | 1.9 (1.1, 3.2) | ||
| PIE | 17 (2.1, 140) | 2.6 (1.5, 4.6) |
Variables offered:
Antenatal epoch: gestational age 23–24 weeks, gestational age 25–26 weeks, birth weight Z-score, sex, complete course of antenatal steroids, multiple birth, cesarean delivery, delivery for preeclampsia or fetal indication, thrombosis of the fetal stem vessels in the placenta
Early neonatal epoch (week 1): SNAP-IITM ≥ 30, confirmed early bacteremia, confirmed tracheal infection, receipt of surfactant, hydrocortisone, dexamethasone, analgesic, sedation, or vitamin A, mechanical ventilation
Late neonatal epoch (weeks 2–4): confirmed bacteremia, confirmed tracheal infection, receipt of hydrocortisone, dexamethasone, analgesics, sedation, or vitamin A, patent ductus arteriosus, pneumothorax, pulmonary interstitial emphysema