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. 2015 Dec 21;112(51-52):884–890. doi: 10.3238/arztebl.2015.0884

Figure 3.

Figure 3

Postulated effects of vasopressin 2 receptor blockade on renal cysts Cyst cells display increased cyclic adenosine monophosphate (cAMP) levels, which can contribute to cyst growth by stimulating ion and fluid secretion, and to cell proliferation by activating protein kinase A (PKA). Antidiuretic hormone (ADH) promotes cAMP production by stimulating vasopressin 2 receptors and activating membrane-bound adenylate cyclases. Vasopressin 2 receptor blockers (V2RBs) can block ADH-dependent cAMP production.