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In vitro validation of SPIO labeling of hMultistem cells. (a) ICP-OES experiments confirmed iron internalization after SPIO labeling (10 ± 1 pg Fe cell−1) but not for unlabeled control cells. (b) Multiecho T2 map (MRI) confirms higher relaxation rats for SPIO labeled cells compared to controls. (c) BLI signal intensity was not significantly affected by SPIO labeling of cells (∗∗∗ p < 0.001).
