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Irb attenuated diabetes-induced MCP-1 expression. (a) Urinary MCP-1 was significantly increased in db/db mice and significantly reduced in db/db mice with treatment of Irb. (b) The mRNA level of MCP-1 in the kidney was increased in the db/db mice and reversed by Irb treatment significantly. The bars in panels (a) and (b) show the mean expression in arbitrary units (error bars, S.D.). ∗ P < 0.05 compared with db/m; # P < 0.05 compared with db/db, t-test.
