Table 2.
Mean values and SD of clinical and laboratory parameters in relation to total assessments and nutritional status.
| Parameter | Total | Eutrophic | Overweight | Obese | p # |
|---|---|---|---|---|---|
| (n = 83) | (n = 32) | (n = 5) | |||
| Prescribed dose% (mg/day) | 2.1 ± 1.3 | 2.0 ± 1.3 | 2.4 ± 1.3 | 2.1 ± 1.4 | 0.250 |
| Adjusted dose%% (mg/Kg) | 0.04 ± 0.03 | 0.05 ± 0.03 | 0.04 ± 0.02 | 0.03 ± 0.02 | 0.343 |
| Time used (months) | 25.9 ± 27.2 | 24.7 ± 27.6 | 29.0 ± 27.0 | 27.4 ± 24.9 | 0.369 |
| Age (years) | 13.0 ± 3.1 | 12.9 ± 2.9 | 13.5 ± 3.6 | 10.7 ± 3.1 | 0.176 |
| Bone age (years) | 13.0 ± 3.1 | 13.0 ± 3.1 | 13.3 ± 3.2 | 10.9 ± 3.0 | 0.305 |
| WC (cm) | 75.4 ± 11.5 | 70.8 ± 9.3 | 86 ± 9.0§ | 84.5 ± 9.2∗ | <0.001 |
| SBP (mmHg) | 102.5 ± 11.8 | 100.6 ± 10.3 | 106.6 ± 12.6§ | 108 ± 21.7 | 0.080 |
| DBP (mmHg) | 63.5 ± 11.3 | 62.1 ± 11.1 | 67.5 ± 10.8§ | 62 ± 14.8 | 0.078 |
| Glycemia (mg/mL) | 85.2 ± 8.5 | 84.2 ± 7.7 | 86.7 ± 8.5 | 93.6 ± 15.0 | 0.120 |
| Insulin (nUI/mL) | 9.4 ± 9.8 | 7.5 ± 8.3 | 14.2 ± 12.0§ | 10.1 ± 8.1 | 0.003 |
| HOMA-IR index | 2.0 ± 2.3 | 1.6 ± 2.1 | 3.0 ± 2.5§ | 2.5 ± 2.0 | 0.002 |
| Total cholesterol (mg/dL) | 156.2 ± 35.9 | 151.4 ± 31.2 | 164.0 ± 43.7 | 184.6 ± 40.7 | 0.096 |
| LDL cholesterol (mg/dL) | 87.5 ± 29.1 | 82.8 ± 26.2 | 96.4 ± 33.2§ | 107.0 ± 31.1 | 0.045 |
| HDL cholesterol (mg/dL) | 52.7 ± 14.1 | 53.9 ± 14.9 | 48.7 ± 12.0 | 57.4 ± 5.9 | 0.119 |
| Triglycerides (mg/dL) | 80.3 ± 45.4 | 73.9 ± 38.6 | 93.5 ± 56.8 | 101.0 ± 55.7 | 0.081 |
| AST (U/L) | 23.4 ± 10.0 | 23.4 ± 10.9 | 22.8 ± 6.7 | 28.2 ± 12.4 | 0.475 |
| ALT (U/L) | 18.4 ± 16.9 | 16.5 ± 17.0 | 21.1 ± 11.8§ | 31.4 ± 33.0 | 0.001 |
| Leptin (pg/mL) | 26.0 ± 16.4 | 19.2 ± 12.7 | 40.8 ± 13.6§ | 44.3 ± 8.5∗ | <0.001 |
WC, waist circumference; SBP, systolic blood pressure; DBP, diastolic blood pressure.
#Kruskal-Wallis test.
§Statistically significant difference (by Mann-Whitney test) between overweight and normal weight.
∗Statistically significant difference (by Mann-Whitney test) between obese and normal weight individuals (p = 0.05).
%Total prescribed risperidone.
%%Prescribed dose of risperidone, but adjusted per kg of body weight.