Table 4.

Absolute and relative frequencies (%) of alleles of SNPs for the presence or absence of clinical and laboratory changes evaluated as discrete variables (n = 120).

	Genotype			χ 2	p
Obese	LEP
	AA	AG	GG
Yes	—	—	5 (10.9)	8.393	0.015§§
No	16 (100)	58 (100)	41 (89.1)
Obese	LEP
	Presence of allele A		Absence of allele A
Yes	—		5 (10.9)	8.393	0.007∗
No	74 (100)		41 (89.1)
Obese or overweight	CYP2D6
	CC	CT	TT
Yes	25 (32.5)	7 (19.4)	5 (71.4)	7.695	0.021§§
No	52 (67.5)	29 (80.6)	2 (28.6)
Obese or overweight	CYP2D6
	Presence of allele C		Absence of allele C
Yes	32 (28.3)		5 (71.4)	5.744	0.028∗
No	81 (71.7)		2 (28.6)
Obese or overweight	HTR2C rs3813929 (Both genders)
	Presence of allele G		Absence of allele G
Yes	33 (35.1)		4 (15.4)	3.714	0.054§
No	61 (64.9)		22 (84.6)
Obese or overweight	Females
	Presence of allele G		Absence of allele G
Yes	8 (47.1)		—	3.697	0.115∗
No	9 (52.9)		5 (100)
Obese or overweight	Males
	Presence of allele G		Absence of allele G
Yes	25 (32.5)		4 (19)	1.426	0.289§
No	52 (67.5)		17 (81)
HOMA-IR	DRD2 rs1799978
	AA	AG	GG
Changed	12 (13.2)	10 (34.5)	—	6.661	0.010§§
Normal	79 (86.8)	19 (65.5)	—
HOMA-IR	DRD2 rs6277
	Presence of allele T		Absence of allele T
Changed	6 (10.9)		16 (24.6)	3.738	0.053§
Normal	49 (89.1)		49 (75.4)
Hypertension	CYP2D6
	CC	CT	TT
Yes	3 (3.9)	3 (8.3)	2 (28.6)	6.509	0.039§§
No	74 (96.1)	33 (91.7)	5 (71.4)
Abdominal circumference	HTR2C rs6318 (both genders)
	C, CC	CG	G, GG
Increased	1 (3.8)	3 (42.9)	16 (18.4)	6.720	0.035§§
Normal	25 (96.2)	4 (57.1)	71 (81.6)
	Females
	CC	CG	GG
Increased	—	2 (40)	—	7.480	0.024§§
Normal	5 (100)	3 (60)	12 (100)
	Males
	C		G
Increased	1 (4.5)		17 (22.4)	3.615	0.066∗
Normal	21 (95.5)		59 (77.6)

^§Chi-square (GL = 1); ^§§Chi-square (GL = 2); ^∗Fisher's exact test.