Figure 4.

Junctional architecture is better preserved with corabion during colitis. Colon cryotissue sections were analyzed by immunofluorescence using antibodies against E-cadherin (red) and ZO-1 (green): (a) control, (b) ctrl + corabion, (c) colitis, and (d) colitis + corabion. Colocalization (yellow) of E-cadherin and ZO-1 at crypt epithelial cell contacts (arrows) is mostly lost in colitis (c) and much better conserved in colitis + corabion (d). A threefold digital zoom of selected crypts is shown to the right which better visualize the preserved colocalization with parallel corabion treatment during colitis (d). Representative images of 3 independent tissue preparations are shown. Bar = 50 μm.