Table 5.
Comparison of the genotype and allele frequencies of the three SNPs in breast cancer patients, grouped on the basis of age of diagnosis, tumor grade, and ER and HER status (only results that have a statistically significant difference between the compared groups are shown).
| Grouping parameter | Group | SNP statistics | ||||
|---|---|---|---|---|---|---|
| Age of diagnosis rs1799796 (A>G) Genotype |
<48 yrs frequency (%) | >48 yrs frequency (%) | OR | CI | χ 2 | p value |
| AA | 51.39 | 30.98 | 0.32 | 0.13–0.8 | 6.05 | 0.014 |
| AG | 33.33 | 40.84 | 2.03 | 0.95–4.3 | 3.42 | 0.06 |
| GG | 15.28 | 28.18 | 3.06 | 1.2–7.6 | 6.05 | 0.013 |
| A | 68.06 | 51.41 | 0.49 | 0.3–0.80 | 8.24 | 0.005 |
| G | 31.94 | 48.59 | 2.01 | |||
|
| ||||||
| Tumour grade rs1799796 (A>G) Genotype |
II frequency (%) | III frequency (%) | OR | CI | χ 2 | p value |
|
| ||||||
| AA | 35.71 | 56.82 | 5.66 | 1.47–21.8 | 7.29 | 0.007 |
| AG | 40.00 | 36.36 | 0.57 | 0.25–1.3 | 1.77 | 0.18 |
| GG | 24.29 | 6.82 | 0.17 | 0.05–0.68 | 7.29 | 0.007 |
| A | 55.71 | 75.00 | 2.38 | 1.32–4.29 | 8.64 | 0.003 |
| G | 44.29 | 25.00 | 0.41 | |||
|
| ||||||
| ER status rs1799796 (A>G) Genotype |
ER− frequency (%) | ER+ frequency (%) | OR | CI | χ 2 | p value |
|
| ||||||
| AA | 43.75 | 36.78 | 0.36 | 0.13–0.97 | 4.24 | 0.039 |
| AG | 41.70 | 36.78 | 1.35 | 0.63–2.88 | 0.60 | 0.44 |
| GG | 14.65 | 26.44 | 2.77 | 1.03–7.45 | 4.24 | 0.04 |
| A | 64.58 | 55.17 | 0.56 | 0.34–0.94 | 4.96 | 0.026 |
| G | 35.42 | 44.83 | 1.77 | |||
|
| ||||||
| HER status rs1799796 (A>G) Genotype |
HER− frequency (%) | HER+ frequency (%) | OR | CI | χ 2 | p value |
|
| ||||||
| AA | 47.89 | 33.80 | 0.29 | 0.11–0.75 | 6.91 | 0.009 |
| AG | 39.43 | 35.34 | 1.26 | 0.59–2.71 | 0.37 | 0.541 |
| GG | 12.68 | 30.88 | 3.45 | 1.3–8.8 | 6.91 | 0.009 |
| A | 67.61 | 51.47 | 0.51 | 0.31–0.83 | 7.52 | 0.006 |
| G | 32.39 | 48.53 | 1.96 | |||
OR = odds ratio; 95% CI = 95% confidence interval; χ 2 = chi square. SNP = single nucleotide polymorphism.