Fig. 6.

Origin and diversification of holozoan bZIPs. Each row represents the putative bZIP complement present in the corresponding LCA (last common ancestor). An hexagon represents a bZIP protein, and the family it belongs to is indicated underneath. Main families are indicated by different colours while subfamilies are indicated with different shades. bZIP subfamilies that had not been reported prior to this study are marked with stripes. Vertical lines represent families or subfamilies that have been conserved throughout metazoan evolution. A double line indicates a duplication event; a fork indicates the divergence of one of the copies. A dotted line reflects an uncertain relationship. In the case of CEBP-PAR and MAF-NFE2, we ascertained that the two subfamilies originated from a single protein but could not identify this ancestor (depicted as an hexagon bearing a question mark). At the bottom, subfamilies are gathered into the traditional bilaterian main families