Table 1.

Observed versus expected analysis of IS incidence post‐Rotarix ^TM vaccination

Risk period (days)	Dose	Number of distributed Rotarix TM doses	Observed number of IS cases (level 1–3 BCWIG)*	Expected number of IS cases†	O/E ratio [95% Poisson CI]
7	1	300 566‡	10	3.37	2.96 [1.42; 5.45]
7	2	300 566‡	5	7.63	0.66 [0.21; 1.53]
7	Any	601 131	15	8.81	1.70 [0.95; 2.81]
30	1	300 566‡	14	14.46	0.97 [0.53; 1.62]
30	2	300 566‡	8	32.70	0.24 [0.11; 0.48]
30	Any	601 131	22	37.75	0.58 [0.37; 0.88]

IS, intussusception; BCWIG, the Brighton Collaboration Intussusception Working Group; O/E, observed versus expected; CI, confidence interval.

^* Includes cases with attributed dose number;

^† Calculated based on the incidence rate reported by Noguchi et al. 8

^‡ Rounded up for clarity.