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. Author manuscript; available in PMC: 2016 Feb 2.
Published in final edited form as: J Hepatol. 2014 Sep 16;62(2):412–420. doi: 10.1016/j.jhep.2014.09.015

Figure 1. Spontaneous liver injury and hepatic steatosis is present in 14 weeks old Arg2−/− mice.

Figure 1

Body weight (A) along with several metabolic parameters – plasma glucose level, plasma insulin level, levels of free fatty acids in plasma, plasma triglycerides – are comparable in Arg2−/− mice and WT mice fed with normal chow (B). However, analysis of liver histology and assessment of hepatic steatosis with Oil Red O staining uncovered the development of liver injury and hepatic steatosis (C) (10× and 40×). In line with this ALT, levels were significantly increased in Arg2−/− mice when compared to WT mice (D). The amount of liver triglycerides was also increased in Arg2−/− (Arg2−/− 4.9 vs. WT 2.6 mg TG/g liver, p <0.05, E). Mean ± S.E.M. are shown. *p<0.05.