Table 1.

Detection of blood-brain barrier permeability with gadolinium and brain deposition in neurological disorders.

Chelating Agent Chemical Structure	BBB Permeability	Brain Deposition	Method of Detection	Neurological Disorders	Number of Injections mean [range]	Interval between 2 Injections	Interval between the First and Last MRI	References
Gadobenate dimeglumine Linear	YES	YES	MRI	Primary Brain tumors, Brain Metastasis, Mutiple Sclerosis, Stroke	4.6 [3–11]	7.8 months	36 months	4,5
Gadopentetate dimeglumineLinear	YES	YES	MRI + MS		4.6 [2–11]	4.6 months	21 months
Gadodiamide Linear	YES	YES	MRI +MS + EM		6.4 [2–29]	7.0 months	45 months
Gadoterate meglumine Macrocyclic	YES	NO	MRI	Primary Brain Tumors, Brain Metastasis, Multiple sclerosis	7.1 [≥6]	5.8 months	41 months	6, 7
Gadoteridol Macrocyclic	YES	NO	MRI + MS		2.6 [2–15]	8.1 months	21 months

BBB, Blood-Brain Barrier; MRI, Magnetic Resonance Imaging; MS, Mass Spectroscopy; EM, Electron Microscopy.