No differences in glucose tolerance (A) or insulin sensitivity (D) were apparent between WT(WTbm) and WT(ARKObm) mice at baseline (prior to high-fat feeding). After 8 weeks of a high-fat diet, a trend was observed toward improved glucose tolerance in WT(ARKObm) mice relative to WT(WTbm) mice (B) in the absence of differences in insulin sensitivity (E). At study termination, glucose tolerance (C) and insulin sensitivity (F) did not differ between groups. *p < 0.05. WT, wild-type; WTbm, WT bone marrow; ARKObm, androgen receptor knockout bone marrow.