Table 1.
Genes differentially expressed (p ≤ 0.01 and 1.5-fold) at a minimum of one time point in UT-SCC-14 xenografts after radiation.
| Gene | n | Day 4 | Day 7 | Day 12 | Day 21 | ||||
|---|---|---|---|---|---|---|---|---|---|
| ↑ | ↓ | ↑ | ↓ | ↑ | ↓ | ↑ | ↑ | ||
| CD44 | 62 | 5 | 3 | 20 | 12 | 28 | 11 | 3 | 4 |
| ALDH | 9 | 2 | 0 | 2 | 4 | 3 | 1 | 1 | 1 |
| MET | 48 | 7 | 1 | 16 | 8 | 25 | 9 | 4 | 5 |
| OCT3/4 | 37 | 6 | 1 | 10 | 5 | 18 | 4 | 4 | 4 |
| BMI1 | 16 | 1 | 0 | 2 | 7 | 6 | 1 | 0 | 1 |
| NOTCH1 | 66 | 7 | 4 | 19 | 14 | 29 | 11 | 1 | 4 |
| NANOG | 29 | 5 | 2 | 7 | 4 | 15 | 4 | 4 | 3 |
| SOX2 | 29 | 3 | 1 | 8 | 5 | 12 | 3 | 1 | 2 |
| CD133 | 20 | 2 | 1 | 3 | 4 | 9 | 3 | 0 | 3 |
| Total | 316 | 38 | 13 | 87 | 63 | 145 | 47 | 18 | 27 |
Using Partek Genomics software and Pathway Studio, genes that were differentially expressed at a minimum of one time point after radiation with a p value ≤ 0.01 and fold change (negative or positive) of 1.5 or greater were identified for each of the CSC-associated genes. For each gene, n represents the total number of identified genes in each pathway whilst the ↑ and ↓ arrows for each day after radiation represent the number of genes which were upregulated or downregulated, respectively.