Table 1.
Association of S100 proteins with different types of gastrointestinal cancer.
| Cancer site | Type of S100 protein | S100 regulated features | References |
|---|---|---|---|
| Colon | S100A8/A9, S100A4, S100A6, S100A11, S100B, S100P | ↑ | [25–28, 31–33, 41–47] |
|
| |||
| Oesophagus | S100A2 | ↓ in ESCC ↑ in adenocarcinoma |
[48, 49] |
| S100A9 | ↑ in adenocarcinoma | [50] | |
|
| |||
| Stomach | S100A2, S100A14 | ↓ | [51, 52] |
| S100A2, S100A3, S100A4, S100A6–S100A10 | ↑ | [53–57] | |
|
| |||
| Pancreas | S100A2 | Dysregulated | [58] |
| S100A4, S100P | ↑ | [59] | |
| S100A11 | ↑ in early stage, ↓ in tumour progression | [60] | |
ESCC, oesophageal squamous cell carcinoma; ↑, upregulated; ↓, downregulated.