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. 2015 Oct 5;128(19):2638–2645. doi: 10.4103/0366-6999.166039

Figure 1.

Figure 1

Alveolar macrophage pyroptosis occurs in vivo after LPS stimulation. Mice were treated with YVAD (6.5 mg/kg, in 1% DMSO in PBS) or DEVD (6.5 mg/kg, in 1% DMSO in PBS) by IP injection 1 h before LPS (20 kg/mg) administration. Alveolar macrophages were isolated from mice after 16 h of LPS administration. Proteins were obtained and caspase-1 P10 and cleaved caspase-3, NLRP3 inflammation activation were analyzed by Western blotting. *P < 0.05 vs. the sham group; †P < 0.05 vs. the LPS + vehicle group; ‡P < 0.05 vs. the LPS + YVAD group. Results are representative of three separate independent experiments.