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. 2015 Oct 5;128(19):2638–2645. doi: 10.4103/0366-6999.166039

Figure 3.

Figure 3

Mice were treated with YVAD (6.5 mg/kg, in 1% DMSO in PBS) or DEVD (6.5 mg/kg, in 1% DMSO in PBS) by IP injection 1 h before LPS (20 kg/mg) administration. (a) Changes in the histology of lung injury after 16 h of LPS administration (H and E, ×400). The arrowheads show alveolar macrophages; (b) The lung injury score; (c)The total number of alveolar macrophages in bronchoalveolar lavage fluid;(d) Water content of lung; (e)The total protein concentration in bronchoalveolar lavage fluid. *P < 0.05 vs. the sham group; †P < 0.05 vs. the LPS + vehicle group; ‡P < 0.05 vs. the LPS + YVAD group. n = 6 mice/group. Results are representative of three separate independent experiments.