Table 1.
Clinical characteristics of MHD patients (n = 110)
| Parameters | Results | Reference range | |
|---|---|---|---|
| Male, n (%) | 64 (58.2) | – | |
| Age (years), mean ± SD | 55.2 ± 1.4 | – | |
| BMI (kg/m2), mean ± SD | 21.3 ± 0.5 | – | |
| Dialysis duration (month) | 29.85 (3.00–225.5) | – | |
| (range) | |||
| Cause of kidney disease | |||
| Glomerular nephritis, n (%) | 63 (57.3) | – | |
| Diabetes mellitus, n (%) | 15 (13.6) | – | |
| Polycystic kidney | 9 (8.2) | – | |
| disease, n (%) | |||
| Gout, n (%) | 5 (4.5) | – | |
| Hypertension | 4 (3.6) | – | |
| nephropathy, n (%) | |||
| Obstructive nephropathy, | 4 (3.6) | – | |
| n (%) | |||
| Unknown, n (%) | 10 (9.1) | – | |
| Pre-ALB (mg/L), mean ± SD | 305.9 ± 6.9 | 180–380 | |
| ALT (IU/L), range | 11 (5–52) | 16–64 | |
| AST (IU/L), range | 13 (5–33) | 8–40 | |
| ALP (IU/L), range | 67.5 (33–1001) | 38.0–126.0 | |
| TP (g/L), range | 63 (35–78) | 60–83 | |
| ALB (g/L), range | 34 (21–58) | 35.0–55.0 | |
| BUN (mmol/L), | 24.9 ± 0.6 | 2.5–7.1 | |
| mean ± SD | |||
| SCR (μmol/L), mean ± SD | 1052.6 ± 24.9 | Male: 62–115; female: 53–97 | |
| UA (μmol/L), mean ± SD | 451.4 ± 7.5 | 160–430 | |
| iPTH (pg/ml) (range) | 243.35 (8.5–2219.0) | 130–600* | |
| 25(OH)D (nmol/L), mean ± SD | 51.6 ± 2.53 | 50.0–80.0 | |
| TG (mmol/L), mean ± SD | 2.32 ± 0.22 | 0.56–1.70 | |
| TC (mmol/L), mean ± SD | 4.07 ± 0.10 | 2.33–5.7 | |
| HDL (mmol/L), mean ± SD | 1.08 ± 0.03 | 0.80–1.80 | |
| LDL (mmol/L), mean ± SD | 2.22 ± 0.07 | 1.30–4.30 | |
| cFGF23 (RU/ml) (range) | 28,683.1 (69.9–351,947.3) | <100* | |
| LgFGF23 (mean ± SD) | 3.86 ± 0.07 | – | |
| P (mg/dl), mean ± SD | 5.77 ± 0.18 | 2.5–4.5† | |
| Ca (mg/dl), mean ± SD | 9.00 ± 0.09 | 8.5–10.0† |
*Our previous study has shown that FGF23 level in general population is <100 Ru/ml, which is consistent with other study; †Reference range according to KDIGO CKD-MBD guideline. BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; TP: Total protein; BUN: Blood urea nitrogen; SCR: Serum creatinine; UA: Uric acid; iPTH: Intact parathyroid hormone; 25(OH)D: 25-hydroxy Vitamin D; TG: Triglyceride; TC: Total cholesterol; HDL: High density lipoprotein; LDL: Low density lipoprotein; FGF23: Fibroblast growth factor 23; P: Phosphate; Ca: Calcium; MHD: Maintenance hemodialysis; ALB: Albumin; CKD-MBD: Chronic kidney disease mineral and bone disorder; KDIGO: Kidney Disease Improve Global Outcomes: Improving Global Outcomes. –: Not available.