Table 2.
Diabetes by overweight/obese type and metabolic health status.
| Diabetes | Metabolically healthy | Metabolically unhealthy | P value | ||
|---|---|---|---|---|---|
| Normal weight | Overweight/obese | Normal weight | Overweight/obese | ||
| (n = 475) | (n = 1594) | (n = 72) | (n = 1106) | ||
| Primary analysis | |||||
| Frequency | |||||
| Yes [n, (%)] | 57 (12.00) | 349 (21.89) | 26 (36.11) | 446 (40.33) | <0.00011 |
| No [n, (%)] | 401 (84.42) | 1208 (75.78) | 42 (58.33) | 641 (57.96) | |
| Weighted OR (95% CI) | |||||
| Unadjusted model | Reference | 2.30 (1.47, 3.60) | 5.20 (2.41, 11.19) | 6.23 (3.94, 9.85) | <0.00012 |
| Multivariable adjusted model 13 | Reference | 2.25 (1.34, 3.79) | 3.78 (1.57, 9.09) | 5.39 (3.16, 9.20) | <0.00012 |
| Multivariable adjusted model 24 | Reference | 2.14 (1.07, 4.28) | 3.18 (1.02, 9.92) | 5.01 (2.43, 10.34) | <0.00012 |
| Sensitivity analysis5 | |||||
| Frequency | |||||
| Yes [n, (%)] | 41 (9.53) | 145 (12.49) | 42 (35.90) | 650 (42.24) | <0.00011 |
| No [n, (%)] | 375 (87.21) | 982 (84.58) | 68 (58.12) | 867 (56.34) | |
| Weighted OR (95% CI) | |||||
| Unadjusted model | Reference | 1.48 (0.87, 2.54) | 4.25 (1.74, 10.37) | 7.81 (4.56, 13.37) | <0.00012 |
| Multivariable adjusted model 13 | Reference | 1.47 (0.83, 2.61) | 2.93 (1.04, 8.23) | 6.25 (3.54, 11.02) | <0.00012 |
| Multivariable adjusted model 24 | Reference | 1.36 (0.59, 3.13) | 3.23 (1.08, 10.01) | 6.57 (2.81, 15.36) | <0.00012 |
1 F approximation of Rao-Scott design adjusted chi-square test P value.
2 P values from Wald chi-square test for the effect of overweight/obese phenotype.
3Adjusted for age at enrollment. Other covariates were not significant and not included in the final model. The models were adjusted for the probability of sampling using weights taking into consideration clustering effects arising from the same census block and household.
4Adjusted for age at enrollment and family history of diabetes. Restricted to the participants who had data for family history of diabetes (n = 2,234, 68%).
5The definition of metabolically health included glucose component.