Table 3.
Genes downregulated in hBMSCs by DEX treatment. Human genes downregulated by at least threefold in hBMSCs treated with DEX for 6 h at P5 compared with nontreated cells.
| Genes | Genebank | Log2 ratio | |
|---|---|---|---|
| EGR2 | Early growth response 2 (Krox-20 homolog, Drosophila), transcript variant 1 | NM_000399 | −4.446 |
| CXCL1 | Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | NM_001511 | −4.060 |
| EGR1 | Early growth response 1 | NM_001964 | −3.989 |
| CXCL2 | Chemokine (C-X-C motif) ligand 2 | NM_002089 | −3.925 |
| ATF3 | Activating transcription factor 3, transcript variant 4 | NM_001040619 | −3.847 |
| EGR3 | Early growth response 3 | NM_004430 | −3.382 |
| NR4A1 | Nuclear receptor subfamily 4, group A, member 1, transcript variant 1 | NM_002135 | −3.312 |
| IER3 | Immediate early response 3 | NM_003897 | −3.294 |
| SERTAD4 | SERTA domain containing 4 | NM_019605 | −3.142 |
| FOS | v-fos FBJ murine osteosarcoma viral oncogene homolog | NM_005252 | −3.050 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B, transcript variant 1 | NM_006732 | −3.042 |
| CXCL3 | Chemokine (C-X-C motif) ligand 3 | NM_002090 | −2.950 |
| ZC3H12A | Zinc finger CCCH-type containing 12A | NM_025079 | −2.949 |
| IL-8 | Interleukin-8 | NM_000584 | −2.917 |
| GDF15 | Growth differentiation factor 15 | NM_004864 | −2.887 |
| IL-6 | Interleukin-6 (interferon, beta 2) | NM_000600 | −2.886 |
| MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | NM_005204 | −2.837 |
| BTG2 | BTG family, member 2 | NM_006763 | −2.669 |
| SEMA6D | Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, transcript variant 6 | NM_024966 | −2.659 |
| PTGS2 | Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | NM_000963 | −2.586 |
| HES1 | Hairy and enhancer of split 1, (Drosophila) | NM_005524 | −2.520 |
| HAS3 | Hyaluronan synthase 3, transcript variant 2 | NM_138612 | −2.502 |
| NCOA7 | Nuclear receptor coactivator 7, transcript variant 1 | NM_181782 | −2.390 |
| EYA1 | Eyes absent homolog 1 (Drosophila), transcript variant 3 | NM_000503 | −2.376 |
| JUNB | Jun B proto-oncogene | NM_002229 | −2.356 |
| C10orf10 | Chromosome 10 open reading frame 10 (C10orf10) | NM_007021 | −2.347 |
| PIM1 | Pim-1 oncogene | NM_002648 | −2.316 |
| ST8SIA1 | ST8 alpha-N-acetyl-neuraminidase alpha-2,8-sialyltransferase 1 | NM_003034 | −2.256 |
| C5orf41 | Chromosome 5 open reading frame 41 (C5orf41) | NM_153607 | −2.251 |
| KLHL24 | Kelch-like 24 (Drosophila) | NM_017644 | −2.248 |
| JUN | Jun oncogene | NM_002228 | −2.247 |
| BCL2L11 | BCL2-like 11 (apoptosis facilitator), transcript variant 1 | NM_138621 | −2.227 |
| EBF3 | Early B-cell factor 3 | NM_001005463 | −2.195 |
| NFκBIZ | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta, transcript variant 1 | NM_031419 | −2.188 |
| AMOTL2 | Angiomotin like 2 | NM_016201 | −2.160 |
| TOX | Thymocyte selection-associated high mobility group box | NM_014729 | −2.149 |
| NUAK2 | NUAK family, SNF1-like kinase, 2 | NM_030952 | −2.112 |
| SASH1 | SAM and SH3 domain containing 1 | NM_015278 | −2.112 |
| SLC40A1 | Solute carrier family 40 (iron-regulated transporter), member 1 | NM_014585 | −2.102 |
| CCL2 | Chemokine (C-C motif) ligand 2 | NM_002982 | −2.089 |
| ID4 | Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | NM_001546 | −2.034 |
| FAM110B | Family with sequence similarity 110, member B | NM_147189 | −2.030 |
| AXUD1 | AXIN1 upregulated 1 | NM_033027 | −2.014 |
| BCL3 | B-cell CLL/lymphoma 3 | NM_005178 | −2.011 |
| ARL4C | ADP-ribosylation factor-like 4C | NM_005737 | −2.011 |
| IER2 | Immediate early response 2 | NM_004907 | −2.009 |
| RASD1 | RAS, dexamethasone-induced 1 | NM_016084 | −2.007 |
| OSR2 | Odd-skipped related 2 (Drosophila), transcript variant 2 | NM_053001 | −1.985 |
| GAB1 | GRB2-associated binding protein 1, transcript variant 1 | NM_207123 | −1.977 |
| TNFAIP3 | Tumor necrosis factor, alpha-induced protein 3 | NM_006290 | −1.954 |
| PDK4 | Pyruvate dehydrogenase kinase, isozyme 4 | NM_002612 | −1.930 |
| BMP4 | Bone morphogenetic protein 4, transcript variant 1 | NM_001202 | −1.867 |
| BDKRB1 | Bradykinin receptor B1 | NM_000710 | −1.849 |
| IRF1 | Interferon regulatory factor 1 | NM_002198 | −1.840 |
| N4BP2L1 | NEDD4 binding protein 2-like 1, transcript variant 1 | NM_052818 | −1.814 |
| ARHGAP20 | Rho GTPase activating protein 20 | NM_020809 | −1.802 |
| NFκBIA | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | NM_020529 | −1.801 |
| CXCR7 | Chemokine (C-X-C motif) receptor 7 | NM_020311 | −1.789 |
| RFTN2 | Raftlin family member 2 | NM_144629 | −1.774 |
| PRICKLE1 | Prickle homolog 1 (Drosophila) | NM_153026 | −1.768 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2, transcript variant 1 | NM_012454 | −1.753 |
| BIRC3 | Baculoviral IAP repeat-containing 3, transcript variant 1 | NM_001165 | −1.751 |
| C5orf4 | Chromosome 5 open reading frame 4, transcript variant 2 | NM_032385 | −1.731 |
| GATA6 | GATA binding protein 6 | NM_005257 | −1.729 |
| CLDN23 | Claudin 23 | NM_194284 | −1.719 |
| TNFRSF11B | Tumor necrosis factor receptor superfamily, member 11b | NM_002546 | −1.700 |
| C2orf67 | Homo sapiens chromosome 2 open reading frame 67 (C2orf67), mRNA [NM_152519] | NM_152519 | −1.693 |
| TRIB3 | Tribbles homolog 3 (Drosophila) | NM_021158 | −1.693 |
| EBF1 | Early B-cell factor 1 | NM_024007 | −1.684 |
| PRAGMIN | Homolog of rat pragma of Rnd2 | NM_001080826 | −1.683 |
| MAFB | v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) | NM_005461 | −1.680 |
| ZFP36 | Zinc finger protein 36, C3H type, homolog (mouse) | NM_003407 | −1.673 |
| IL-7 | Interleukin-7 | NM_000880 | −1.642 |
| RUNX1T1 | Runt-related transcription factor 1; translocated to, 1 (cyclin D-related), transcript variant 1 | NM_004349 | −1.628 |
| HK2 | Hexokinase 2 | NM_000189 | −1.623 |
|
| |||
| EPHA5 | EPH receptor A5, transcript variant 1 | NM_004439 | −1.186 |
A total of 28,780 human genes consistent with the quality criteria, genes downregulated twofold or higher are listed.