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. 2015 Jul 7;34(1):106–120. doi: 10.1002/jor.22963

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© 2015 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc. on behalf of Orthopaedic Research Society

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Digestion of crude equine cartilage proteoglycan with MMP‐3 or ADAMTS‐4 produced a number of neopeptides. Histogram of neopeptides identified following a Mascot search of the Unihorse database following protease digestion with either ADAMTS‐4 or MMP‐3 or in control conditions of crude equine proteoglycan extract. Results were from the pooled proteoglycan‐rich extract from three donors analyzed on the instrument in singlicate. Peptides included in the histogram were exclusively identified in the samples assigned. The control contained digestion buffer but no exogenous protease.